Mesenchymal Stromal Cell Homing: Mechanisms and Strategies for Improvement
نویسندگان
چکیده
منابع مشابه
Mechanisms of mesenchymal stromal cell immunomodulation.
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years, the initial observations that MSCs could enhance regeneration and modulate immune responses have been significantly advanced and we now have a clearer picture of the effects that MSCs have on the immune system partic...
متن کاملP-58: Mesenchymal Stromal Cell Cultures from Human Testis Tissue Cryopreservation and Their Potential for The Future Cell Therapy Applications
N;
متن کاملStrategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy.
Stem/progenitor cell-based therapeutic approach in clinical practice has been an elusive dream in medical sciences, and improvement of stem cell homing is one of major challenges in cell therapy programs. Stem/progenitor cells have a homing response to injured tissues/organs, mediated by interactions of chemokine receptors expressed on the cells and chemokines secreted by the injured tissue. Fo...
متن کاملChallenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies
Cell-based therapies have the potential to revolutionize current treatments for diseases with high prevalence and related economic and social burden. Unfortunately, clinical trials have made only modest improvements in restoring normal function to degenerating tissues. This limitation is due, at least in part, to the death of transplanted cells within a few hours after transplant due to a combi...
متن کاملXeno-Free Strategies for Safe Human Mesenchymal Stem/Stromal Cell Expansion: Supplements and Coatings
Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring in vitro expansion. Most of the current protocols for hMSC expansion make use o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: iScience
سال: 2019
ISSN: 2589-0042
DOI: 10.1016/j.isci.2019.05.004